Atopic Dermatitis

The atopic skin condition is caused by genetic factors, which affect skin structure and its defensive responses to the environment. Normally, the skin protects the body from environmental pollutants and allergens, like the chlorine in a swimming pool. But for those with atopic skin, this barrier is less effective and more fragile. As a result, the skin is more sensitive, prone to cracking and itching, and is less resistant to damage.

Itching

Atopic dermatitis is a common skin condition that causes intense itching. It is caused by an immune reaction to an allergen in the skin. This reaction can lead to open sores and cracks that can be infected. These sores can become life-threatening if not treated in a timely fashion. The condition affects both infants and adults and differs in severity from person to person. In infants, the condition can lead to difficulty sleeping and the scratching can lead to skin infections. In children, itchy skin is often accompanied by dry, scaly skin. The problem can be so disruptive to daily life that it can cause sleep problems and affect overall quality of life.

The root cause of atopic dermatitis is not known, but genetic factors are believed to play a role. Genetics can affect the production of skin cells and cause it to react to certain triggers. Those who have the disorder tend to have very dry skin, which may make it more susceptible to triggers. In some cases, the disease can be hereditary – if you have a family member with it, you are more likely to develop it. In addition, the disease is not contagious and cannot be passed from person to person through close contact.

Redness

Redness due to atopic skin can be caused by a number of different factors. These factors may include exposure to environmental allergens, food allergies, and house mites. It can also be caused by genetic differences. Regardless of its cause, this disease is characterized by intense itching and rashes. The skin also develops a weakened protective layer that is susceptible to damage. This results in an increase in the risk of infection, as the patient may scratch the affected skin.

The best way to diagnose redness due to atopic skin is to visit your doctor and get tested for any allergies that you may have. You should also ask the doctor about any history of the condition. Some people with this skin condition may have other health problems such as asthma.

Cracking

If you’ve noticed cracking on your atopic skin, you may want to seek medical treatment. It’s important to treat cracks immediately to prevent severe infections. If left untreated, these infections can progress to a systemic disease, known as sepsis. In severe cases, your doctor may prescribe antibiotics.

The changes in the skin’s protective layer may result in itchiness and dryness. This in turn can lead to damage and inflammation. When this occurs, patients may scratch their skin, causing further damage and increasing their risk of infection.

Filaggrin expression

Several studies have demonstrated that loss-of-function mutations in the Filaggrin gene lead to an increased risk of atopic dermatitis. In mice with the FLG mutation, the expression of the filaggrin gene is reduced. This reduction of filaggrin is accompanied by an increased expression of IL-4 and IL-13, which are both associated with increased inflammatory response.

Filaggrin is an intracellular protein produced by keratinocytes. It is an important component of keratohyalin granules. Its conversion to a more soluble form occurs through serine protease hydrolysis. During this process, the level of filaggrin and loricrin decreases.

Environmental allergens

Environmental allergens are known to trigger eczema symptoms. They can include dust mites, pollen, and pet dander. Treatments include aggressive moisturizing, antihistamines, and topical corticosteroids. Some patients may also undergo allergy shots.

Treatment

Treatment for atopic skin begins with finding the underlying cause and identifying the trigger. This condition is most commonly found on the face, but can occur on any part of the body. In infants, it typically affects the face and neck, but can also affect the hands, arms, thighs, and abdomen.

While there is no known cure for atopic dermatitis, there are several effective treatments available. One of these is the regular use of emollients, which help restore and preserve moisture in the skin. The other common treatment for atopic skin is corticosteroids or immunomodulators.