Causes of Atopic Skin Disease

One of the many causes of atopic skin disease is genetics. But atopic skin disease can also be the result of environmental factors. Here are some factors that influence the development of atopic skin disease. If you have a darker skin tone, you are at a higher risk for developing atopic dermatitis.

Allergic contact dermatitis

The treatment for allergic contact dermatitis and atopic dermatitis is similar and often involves reducing the itching and inflammation. It is also important to prevent recurrences of the condition. This means knowing which substances trigger an allergic reaction and avoiding them.

Some common allergens include nickel in jewelry and perfumes, irritants in clothing, and chemicals in shoes. However, less well-known allergens include hydrocortisone cream, antibiotic creams, benzocaine, and thimerosal. However, contact dermatitis can also occur from common household products such as laundry detergents.

Both atopic dermatitis and allergic contact dermatitis are characterized by itchy, scaly, and dry skin. Atopic dermatitis rashes can be found on one or both sides of the body. In both cases, an underlying genetic mutation results in the breakdown of the skin’s protective barrier, called filaggrin. This weakened barrier allows allergens to penetrate the skin and cause allergic inflammation. The rash becomes red and irritable, and the person may scratch it in an attempt to relieve the itch. This further disturbs the skin, leading to more itching and inflammation.


The genetics of atopic skin is a major focus of a number of recent studies. This includes studies of DNA methylation, epigenetics, transcriptomic analysis, and 3D genome organization, all of which are crucial for cell differentiation and development. Studies by Fraser and Schoenfelder have focused on gene expression control and long-range enhancer-promoter contacts in atopic dermatitis.

One gene implicated in atopic skin is FLG. This gene codes for profilaggrin, a protein that is found in the epidermis. Mutations in this gene can increase the skin’s permeability and sensitivity. Other genes may also be involved in the development of atopic skin.

Environmental factors

It’s difficult to pinpoint what causes atopic skin disease (AD), but environmental factors can affect the disease. Some researchers suggest that climate change may be one factor in the development of the disease. These factors include shifting patterns in temperature and humidity, and extreme weather events. Regardless of cause, atopic dermatitis can be very uncomfortable and disabling.

Atopic dermatitis has multiple factors, including genetics, immune system function, prenatal exposures, and climate. Environmental factors can include: air pollution, bacterial endotoxins, temperature, and humidity. Water hardness is another potential factor. In some cases, atopic skin can be triggered by probiotics or by exposure to tobacco smoke.


The most effective treatment for atopic skin is a topical cream or gel that contains soothing, nourishing plant oils and antibacterial ingredients. Combined with regular skin care, these treatments can help reduce the frequency and severity of flare-ups. A good cream or gel also contains antibacterial ingredients that fight the growth of staphylococcus aureus, which causes the skin to become dry and inflamed.

Atopic dermatitis is an ongoing chronic skin condition. There is no known cure for the disease. However, there are several treatments for the condition. Some of them can improve the symptoms and even lengthen the time a person will be able to experience remission.