The Role of IL-13 and IL-15 in Atopic Dermatitis

There are some things you can do to help reduce the outbreaks of atopic skin. These include avoiding the use of soap and other chemicals and staying away from wool and certain synthetic fibers. A good moisturizer will also help decrease the outbreaks and the need for medical treatment. If you have atopic skin, you should also avoid wearing wool or certain types of clothing to avoid irritating the affected skin.


The role of IL-31 in atopic skin inflammation is not completely understood, but it is believed to contribute to inflammation. IL-31 stimulates production of several proinflammatory cytokines, such as TNF-alpha, and is also involved in the remodeling of tissues. It is also associated with T cells and dendritic cells.


Inflammatory skin diseases are caused by an imbalance of T helper 1 and T helper 2 cells. Atopic dermatitis (AD) is a chronic and relapsing condition that affects children more frequently than adults. Cytokines are emerging as important regulators of these diseases, but little is known about how they affect these diseases in vivo. Therefore, this study was conducted to determine if IL-6 levels in the blood of children with AD were associated with disease severity.


There are two types of allergic reactions in the body: innate and acquired. It is possible to classify atopic dermatitis according to the type of allergic response. One is IgE/stat6-dependent, while the other is IL-8-dependent. Both types produce inflammatory reactions and contribute to the inflammatory process of the skin.


IL-13 is a major cytokine produced by Th2 cells and type 2 innate lymphoid cells that plays a pivotal role in atopic dermatitis (AD). This cytokine inhibits the epidermal barrier and induces a phenotypic atopic inflammatory response by binding to heterodimeric receptors and downregulating epidermal differentiation molecules. In addition, IL-13 induces itch sensation by activating sensory nerves in the epidermis. IL-13 is also thought to induce fibrosis and lichenification.


IL-15 is a type of cytokine expressed by monocytes and macrophages. This cytokine is thought to be important for the pathogenesis of psoriasis. Moreover, IL-15 has a similar role in other inflammatory diseases like rheumatoid arthritis.


A number of studies have suggested a correlation between the cytokine IL-16 and atopic skin. The cytokine is produced by mast cells and eosinophils. The presence of IL-16 in the blood is also associated with increased levels of inflammatory cytokines.


IL-21 is an important cytokine that is expressed on the skin of individuals with atopic dermatitis. It plays a role in the mobilization of DC and DLN and in the allergic response to ec introduced allergens. This article will discuss some of the research on the role of IL-21 and atopic skin.


The IL-22 gene is expressed in both lesional and non-lesional skin. Various studies have investigated the role of IL-22 in these different types of skin.