Vesicules on Skin Caused by Allergies and Atopic Dermatitis

Small vesicles

Small vesicles on the skin can be caused by a variety of conditions, including allergies and atopic dermatitis. In most cases, they can be treated using over-the-counter treatments and home remedies. However, if they spread rapidly or become infected, a visit to a physician may be necessary. There are a number of treatments available, including topical steroids and antibiotics.

A physician may perform a physical exam to determine the underlying cause of the small vesicles. If they are caused by an allergic reaction, the doctor may recommend antihistamines for the itch and inflammation. If the rash has become severe, a doctor may prescribe a corticosteroid cream. The rash may initially appear as pink macules, but over time, they may enlarge into vesicles.

Barrier defects

The epidermal barrier plays an important role in atopic dermatitis pathogenesis. However, its integrity is compromised due to changes in the immune response. These changes in the skin barrier have been associated with inflammation and increased permeability. Thus, interventions that improve the barrier function may help prevent or delay the progression of the disease.

The causes of atopic dermatitis are not fully understood. The disease has increased in frequency over the past several decades, affecting about 20 percent of the population in the developed world. Genetic studies have shown that atopic skin disease is heritable. It has been linked to specific genetic variants, such as a loss of function in the filaggrin gene, which facilitates epidermal differentiation and formation of the skin barrier.

The defects of the skin barrier are most common in the stratum corneum, the outermost layer of the epidermis. The skin’s barrier functions by providing a physical barrier to the external environment and protecting the body from water loss. In addition, the skin also contains infiltrating and resident immune cells. The stratified multilayered epidermis has four layers, each with its own function. The epidermis consists of keratinocytes that are anchored to the basement membrane by complex multiprotein structures called desmosomes and hemidesmosomes. In addition, keratinocytes are in a constant self-renewal cycle and are the main component of the epidermis.

Inflammatory mediators

Inflammatory mediators are involved in the process of inflammation in skin. This process is regulated by immune system chemicals that affect skin cells. The levels of these chemicals are higher in people with atopic dermatitis than in healthy skin. Moreover, the increased concentration of these chemicals in atopic skin is associated with increased risk for cardiovascular disease.

Besides regulating cellular immunity, inflammatory mediators also promote cutaneous inflammation. Therefore, they may be involved in the biochemical processes that lead to AD.


Atopic dermatitis can be a painful condition. Fortunately, there are several effective treatments available to alleviate its symptoms. These include topical emollients that moisturize the skin and reduce the occurrence of flare-ups. Ideally, these products should also contain soothing active ingredients, nourishing plant oils, and antibacterial agents that prevent the growth of staphylococcus aureus.

Atopic dermatitis is a chronic condition that is triggered by disturbances in the immune system. Common symptoms include itching, redness, keratinization of skin, and exudates. It is associated with various allergic diseases and can significantly impact a person’s quality of life. In addition, the condition can result in higher health care costs.

The most important treatment for atopic eczema is daily moisturizing. Moisturizing the skin daily will help strengthen its protective hydrolipidic layer and help space out flare-ups. It is important to start applying emollients to a child as soon as possible after birth and continue until the child has no more symptoms. Choose a product specifically for atopic eczema to help alleviate symptoms.